#1 - Sept. 9, 2011, 9:41 p.m.
I've done this with WoW and starcraft 2 and most of the time it works fine.
Usually in older legacy games such as D2 the overlay does not work.
Well with D3 the steam overlay is not working. Thought i'd put it out there since i know of quite a few people who open their games with steam as well.